Tatiana Hurtado de Mendoza

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Estudios y Posiciones de Trabajo

2012- present  Postdoctoral Fellow, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

2009-2012      Postdoctoral Fellow, The Salk Institute for Biological Studies, La Jolla, CA

2003-2009      Estudiante de Doctorado, UCSD/The Salk Institute for Biological Studies, La Jolla, CA

2000-2003      Research Assistant, University of California, San Diego, San Diego, CA

1994-2000      BSc Bioquimica y Biologia Molecular, Universidad Autonoma de Madrid, Espana

Areas de trabajo

Terapia contra el cancer centrada en como hacer llegar los agentes terapeuticos especificamente a los tumores para reducir los efectos secundarios y la toxicidad de las terapias actuales y a su vez mejorar su eficacia.

Otra area es la inmunoterapia, que consisteen como ayudar a tu sistema inmunitario a combatir los tumores.

Estudio de la metastasis tumoral y de como prevenirla. 

Publicaciones

  1. Hurtado de Mendoza, T, Braun, G.B, Kotamraju, V.R, Teesalu, T, Ruoslahti, E and Sugahara, K.N. iRGD targets cancer associated fibroblasts and uses the stroma as a conduit to spread through the tumor tissue (in preparation)
  2. Hurtado de Mendoza T, Liu F, Verma IM (2015) Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response. PLoS ONE 10(11): e0142161. doi:10.1371/journal.pone.0142161
  3. Sugahara, K.N, Scodeller, P, Braun, G.B, Hurtado de Mendoza, T, Kitayama, J, Alvarez, E, Howell, S.B, Teesalu, T, Ruoslahti, E and Lowy, A.M (2015). A tumor-penetrating peptide enhances circulation-independent drug delivery to peritoneal carcinomatosis. Journal of Controlled Release (2015), doi:10.1016/j.jconrel.2015.06.009
  4. Sugahara, K.N, Braun, G.B, Hurtado de Mendoza, T, Kotamraju, V.R, French, R.P, Lowy, A.M, Teesalu, T and Ruoslahti, E (2014). Tumor-Penetrating iRGD Peptide Inhibits Metastasis. Mol Cancer Ther. 2014 November 12. pii: molcanther. 0366.2014

5.      Braun, G.B, Friman, T, Pang, H-B, Pallaoro, A, Hurtado de Mendoza, T, Willmore, A-M.A, Kotamraju, V.R, Mann, A.P, She, Z-G, Sugahara, K.N, Reich, N.O, Teesalu, T and Ruoslahti, E. (2014). Etchable Plasmonic Nanoparticle Probes to Image and Quantify Cellular Internalization. Nat Mater. 2014 Sep; 13(9):904-11. doi:10.1038/nmat3982

  1. Yau, I.W, Cato, M.H, Jellusova, J, Hurtado de Mendoza, T, Brink, R, and Rickert, R.C. (2013). Censoring of Self-Reactive B Cells by Follicular Dendritic Cell-Displayed Self-Antigen. J Immunol 2013; 191:1082-1090
  2. Hurtado de Mendoza, T, Perez-Garcia, C. G, Kroll, T. T, Hoong, N. H, O’Leary, D. D, and Verma, I. M. (2011). Antiapoptotic Protein Lifeguard is Required for Survival and Maintenance of Purkinje and Granular Cells. Proc Natl Acad Sci U S A 108:17189-17194
  3. Hurtado de Mendoza, T, Balana, B, Slesinger, P.A, Verma, I.M. (2011) Organotypic Cerebellar Cultures: Apoptotic Challenges and Detection. J Vis Exp, 10.3791/2564
  4. Xia, Y., Padre, R.C, Hurtado de Mendoza, T, Bottero, V, Tergaonkar, V.B, and Verma, I.M. (2009). Phosphorylation of p53 by IkappaB kinase 2 Promotes its Degradation by beta-TrCP. Proc Natl Acad Sci U S A 106:2629-34